Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo

Abstract

Anti–MERS-CoV human IgG produced from transchromosomic bovines neutralizes MERS-CoV in vitro and in vivo.

Document Details

Document Type
Pub Defense Publication
Publication Date
Feb 17, 2016
Source ID
10.1126/scitranslmed.aaf1061

Entities

People

  • Britini L. Ork
  • Christopher M. Coleman
  • David Flyer
  • Eddie J. Sullivan
  • Elena N. Postnikova
  • Gabriel Defang
  • Gale Smith
  • Gene G. Olinger
  • Gregory Glenn
  • Hiroaki Matsushita
  • Hua Wu
  • Jens H. Kuhn
  • Jin-an Jiao
  • Jincun Zhao
  • Jonathan Wang
  • Kanakatte Raviprakash
  • Lisa Hensley
  • Matthew B. Frieman
  • Michael R. Holbrook
  • Reed F. Johnson
  • Rudragouda Channappanavar
  • Stanley Perlman
  • Tadeusz Kochel
  • Thomas Luke
  • Wensheng Nie
  • Ye Liu

Organizations

  • First Affiliated Hospital of Guangzhou Medical University
  • National Institute of Allergy and Infectious Diseases
  • National Institutes of Health
  • Naval Medical Research Unit Three
  • Thermo Fisher Scientific Inc.
  • University of Iowa
  • University of Maryland School of Medicine

Tags

Fields of Study

  • Biology