The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation
Abstract
The brain microenvironment triggers HER3-dependent de novo resistance to therapies targeting PI3K or HER2 in HER2-positive and/or PIK3CA -mutant breast cancer cells.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 24, 2017
- Source ID
- 10.1126/scitranslmed.aal4682
Entities
People
- Alan Huang
- Angela Tam
- Bhushankumar Patel
- C. Ryan Miller
- Carey K. Anders
- Carlos L Arteaga
- Carlotta Costa
- Christina Wong
- Dai Fukumura
- Dan G Duda
- David P Kodack
- Divya Bezwada
- Elena Brachtel
- Gino B. Ferraro
- Jantima Tanboon
- Jeffrey A. Engelman
- Jonas Kloepper
- Kamila Naxerova
- Mark Badeaux
- Marni B Siegel
- Melinda E. Sanders
- Mónica Valeria Estrada
- Qing Sheng
- Rakesh Jain
- Rakesh R Ramjiawan
- Ram C Shankaraiah
- Rita Das
- Robert Schlegel
- Shom Goel
- Vasileios Askoxylakis
- Xiaolong Qi
- Yongchul Song
- Z. Alexander Cao
Organizations
- German Research Foundation
- Harvard Medical School
- KWF Kankerbestrijding
- National Cancer Institute
- Susan G. Komen for the Cure
- United States Department of Defense
- University of North Carolina
- Vanderbilt-Ingram Cancer Center