Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen–specific CTLs
Abstract
PVSRIPO infection of tumors elicits antitumor immunity by damaging neoplastic cells and activating type I IFN responses in antigen-presenting cells.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 20, 2017
- Source ID
- 10.1126/scitranslmed.aan4220
Entities
People
- Darell D. Bigner
- David Boczkowski
- Eda K Holl
- Elena Dobrikova
- Matthias Gromeier
- Michael C Brown
- Mubeen Mosaheb
- Smita K Nair
- Vidyalakshmi Chandramohan
Organizations
- Duke University
- National Cancer Institute
- United States Department of Defense