A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates
Abstract
The small-molecule AT-121 is an agonist of nociceptin and mu opioid peptide receptors and mediates analgesia without opioid-associated side effects in nonhuman primates.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 29, 2018
- Source ID
- 10.1126/scitranslmed.aar3483
Entities
People
- Dennis Yasuda
- Huiping Ding
- James J. Lu
- Mei-Chuan Ko
- Norikazu Kiguchi
- Nurulain T Zaveri
- Pankaj Daga
- Paul W Czoty
- Shiroh Kishioka
- Willma E. Polgar
Organizations
- National Institute on Drug Abuse
- United States Department of Defense
- Wakayama Medical University
- Wake Forest School of Medicine