The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling
Abstract
Inactivation of the Fmr1 gene that is mutated in fragile X syndrome leads to loss of retinoic acid–mediated homeostatic plasticity in human neurons.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 01, 2018
- Source ID
- 10.1126/scitranslmed.aar4338
Entities
People
- Bo Zhou
- Christopher Patzke
- Kristin L Arendt
- Lu Chen
- Marius Wernig
- Nan Yang
- Samuele Marro
- Thomas C. Südhof
- Tyler Fair
- Yingsha Zhang
- Zhenjie Zhang
Organizations
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Fraxa Research Foundation
- Howard Hughes Medical Institute
- National Institute of Mental Health
- New York Stem Cell Foundation
- Stanford University
- United States Department of Defense