Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer

Abstract

PD-L1 + tumor cells, but not macrophages, are likely responsible for inhibiting tumor-specific T cells in early-stage human lung tumors.

Document Details

Document Type
Pub Defense Publication
Publication Date
Feb 13, 2019
Source ID
10.1126/scitranslmed.aat1500

Entities

People

  • Abhishek S. Rao
  • Edmund K Moon
  • Edward Cantu
  • Evgeniy B Eruslanov
  • Gwenn Danet-Desnoyers
  • Hyun-jeong Ra
  • Jason E Stadanlick
  • Leslie Litzky
  • Michael J. Annunziata
  • Pratik S Bhojnagarwala
  • Shaun O'Brien
  • Steven M. Albelda
  • Sunil Singhal
  • Tatiana Akimova
  • Ulf H Beier
  • Wayne W Hancock

Organizations

  • Children's Hospital of Philadelphia
  • National Cancer Institute
  • National Heart, Lung, and Blood Institute
  • United States Department of Defense
  • University of Pennsylvania

Tags

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Molecular and Cellular Biology
  • Oncology