A T164S mutation in the dengue virus NS1 protein is associated with greater disease severity in mice

Abstract

The T164S mutation in the NS1 protein of dengue virus increases disease severity in mice through complement activation.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jun 26, 2019
Source ID
10.1126/scitranslmed.aat7726

Entities

People

  • Bo Burla
  • Dhanasekaran Vijaykrishna
  • Don Teng
  • Eng Eong Ooi
  • Federico Torta
  • Jan K. Marzinek
  • Jocelyn Y. Jin
  • Julien Pompon
  • Kitti W K Chan
  • Markus R. Wenk
  • Peter J. Bond
  • Satoru Watanabe
  • Scott B. Halstead
  • Subhash G Vasudevan
  • Sylvie Alonso

Organizations

  • Bioinformatics Institute
  • Duke–NUS Medical School
  • Ministry of Education
  • Monash University
  • National Medical Research Council
  • National Research Foundation
  • Uniformed Services University of the Health Sciences
  • University of Montpellier

Tags

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biology
  • Virology (or Medical Virology).