The androgen receptor regulates a druggable translational regulon in advanced prostate cancer
Abstract
The androgen receptor (AR) regulates mRNA-specific translation through 4EBP1, which is a druggable vulnerability in AR-deficient prostate cancer.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 31, 2019
- Source ID
- 10.1126/scitranslmed.aaw4993
Entities
People
- Alexandre A Germanos
- Andrew C Hsieh
- Asha Z. Goodman
- Brett S. Carver
- Colm Morrissey
- Elise Y Cai
- Eva Corey
- Ilsa M. Coleman
- Jessie L Horn
- Kalyan Banda
- Lexiaochuan Wen
- Peter S Nelson
- Robin G. Tharakan
- Slobodan Beronja
- Smitha P. S. Pillai
- Sonali Arora
- Stephen R Plymate
- Sujata Jana
- Takuma Uo
- William R Hardin
- Yiting Lim
- Yu Chen
- Yu Chi Yang
- Yuzhen Liu
Organizations
- American Association for Cancer Research
- American Society of Clinical Oncology
- Burroughs Wellcome Fund
- Fred Hutchinson Cancer Center
- Memorial Sloan Kettering Cancer Center
- Office of the Director
- United States Department of Defense
- University of Washington
- V Foundation for Cancer Research