Reproducing human and cross-species drug toxicities using a Liver-Chip

Abstract

A rat, dog, and human Liver-Chip designed using microengineered Organs-on-Chips technology recapitulates species-specific drug toxicities.

Document Details

• Document Type: Pub Defense Publication
• Publication Date: Nov 06, 2019
• Source ID: 10.1126/scitranslmed.aax5516

Entities

People

• Abhishek Srivastava
• Anna Herland
• Anthony J Streeter
• Barry Jones
• Bhanu Singh
• Carl Manthey
• Damir Simic
• David Conegliano
• Debora B Petropolis
• Dominic P Williams
• Donald E. Ingber
• Erio Barale-Thomas
• Gauri Kulkarni
• Heng-Keang Lim
• Hyoungshin Park
• Janey Ronxhi
• Janna C Nawroth
• Jonathan E Rubins
• Josiah Sliz
• Katia Karalis
• Konstantia R Kodella
• Kyung-Jin Jang
• Linda C Andersson
• Lorna Ewart
• Manisha Sonee
• Monica Singer
• Monicah A Otieno
• Riccardo Barrile
• Suzzette Haney
• Wing Lam

Organizations

• AstraZeneca
• Defense Advanced Research Projects Agency
• Harvard Medical School
• Harvard University
• Janssen Biotech
• Janssen Pharmaceuticals