Delivery of single-domain antibodies into neurons using a chimeric toxin–based platform is therapeutic in mouse models of botulism
Abstract
A detoxified chimeric toxin–based platform delivers therapeutics into neurons and has therapeutic effects in mouse models of botulism.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 06, 2021
- Source ID
- 10.1126/scitranslmed.aaz4197
Entities
People
- Charles B Shoemaker
- Jie Zhang
- Min Dong
- Shin-Ichiro Miyashita
- Sicai Zhang
Organizations
- Boston Children's Hospital
- Harvard Medical School
- Intelligence Advanced Research Projects Activity
- National Institute of Allergy and Infectious Diseases
- National Institute of Neurological Disorders and Stroke
- Tufts University