PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity
Abstract
PRMT5 expression in melanoma suppresses inflammation and antigen presentation, suggesting that its inhibition could potentiate immunotherapy.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 08, 2020
- Source ID
- 10.1126/scitranslmed.aaz5683
Entities
People
- Heejung Kim
- Hironari Tamiya
- Hyungsoo Kim
- Stefania Tocci
- Yan Li
- Yongmei Feng
- Zeev Ronai
Organizations
- Melanoma Research Alliance
- National Institutes of Health
- Sanford Burnham Prebys Medical Discovery Institute
- Technion – Israel Institute of Technology