CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice
Abstract
Human white adipocytes engineered to express UCP1 activate endogenous BAT and protect against diet-induced obesity when transplanted into mice.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 26, 2020
- Source ID
- 10.1126/scitranslmed.aaz8664
Entities
People
- Accalia Fu
- Bennett P. Greenwood
- Brice Emanuelli
- Chih-Hao Wang
- Farnaz Shamsi
- Justin Darcy
- Kyle L Smith
- Luiz O Leiria
- Matthew D Lynes
- Michael A Kiebish
- Morten Lundh
- Nika N Danial
- Niven R Narain
- Rókus Kriszt
- Susan Hagen
- Tian Lian Huang
- Vladimir V. Tolstikov
- Young-Tae Chang
- Yu-Hua Tseng
Organizations
- American Dental Association
- American Heart Association
- Beth Israel Deaconess Medical Center
- China Medical University
- Danish Agency for Science and Higher Education
- Harvard Medical School
- Harvard University
- Institute for Basic Science
- JDRF
- National Science and Technology Council
- Novo Nordisk Foundation Center for Basic Metabolic Research
- Office of the Director
- São Paulo Research Foundation
- United States Army Medical Research and Development Command
- University of Copenhagen
- University of São Paulo
- Yusuf Hamied Department of Chemistry