iPSC–endothelial cell phenotypic drug screening and in silico analyses identify tyrphostin-AG1296 for pulmonary arterial hypertension

Abstract

Drug screening for improved function and transcriptomics of iPSC-derived endothelial cells from patients with pulmonary hypertension reveals AG1296.

Document Details

Document Type
Pub Defense Publication
Publication Date
May 05, 2021
Source ID
10.1126/scitranslmed.aba6480

Entities

People

  • Lingli Wang
  • Marlene Rabinovitch
  • Michele Donato
  • Mingxia Gu
  • Minzhe Guo
  • Neil Wary
  • Purvesh Khatri
  • Rebecca L. Harper
  • Shoichiro Otsuki
  • Shuai Mao
  • Silin Sa
  • Toshie Saito
  • Yifei Miao

Organizations

  • Gates Foundation
  • Office of the Director
  • Stanford University
  • United States Department of Defense
  • University of Cincinnati

Tags

Fields of Study

  • Biology
  • Medicine

Readers

  • Cardiovascular Physiology
  • Computational Modeling and Simulation
  • Molecular and Cellular Biology