Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice
Abstract
A cAMP-dependent mechanism mediates seizures in mTOR disorders due to the ectopic expression of HCN4 channels in diseased neurons.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 18, 2020
- Source ID
- 10.1126/scitranslmed.abc1492
Entities
People
- Angélique Bordey
- Dennis D. Spencer
- John H. Wen
- Juan Torres-Reveron
- Lawrence S Hsieh
- Lena H Nguyen
- Longbo Zhang
- Stephanie A Getz
- Ying Wang
Organizations
- American Epilepsy Society
- Central South University
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- National Natural Science Foundation of China
- United States Department of Defense
- Yale University