Whole-exome sequencing reveals germline-mutated small cell lung cancer subtype with favorable response to DNA repair–targeted therapies
Abstract
Heritable defects in cancer genes define a subset of small cell lung cancer with distinct therapeutic vulnerabilities.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 27, 2021
- Source ID
- 10.1126/scitranslmed.abc7488
Entities
People
- Anish Thomas
- Arun Rajan
- Camille Tlemsani
- Chul Kim
- Clesson E Turner
- Grace-ann Fasaye
- Javed Khan
- Jun S Wei
- Kathleen Calzone
- Keith T. Schmidt
- Linda Sciuto
- Lőrinc Pongor
- Manoj Tyagi
- Nobuyuki Takahashi
- Parth Desai
- Rasa Vilimas
- Samantha Nichols
- Santhana Webb
- Seth M Steinberg
- Shannon Swift
- Udayan Guha
- Vinodh N Rajapakse
- William Douglas Figg, Sr.
- Xinyu Wen
- Yves Pommier
Organizations
- Georgetown University
- National Cancer Institute
- Walter Reed National Military Medical Center