Dynamic loading of human engineered heart tissue enhances contractile function and drives a desmosome-linked disease phenotype
Abstract
A dynamic mechanical loading platform was developed to improve contractility of engineered heart tissues and study cardiac disease progression.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 21, 2021
- Source ID
- 10.1126/scitranslmed.abd1817
Entities
People
- Adam W Feinberg
- Albert J. H. Suurmeijer
- Alexander Teplenin
- Andrew R Lee
- Anna Kalmykov
- Brian Coffin
- Daniel A Pijnappels
- Daniel J Shiwarski
- Duco Kramer
- Ivan Batalov
- Jacqueline Bliley
- Jan D.H. Jongbloed
- Joshua Tashman
- Linda Volkers
- M. Vermeer
- Maria C. Bolling
- Martijn Hoes
- Nils Bomer
- Peter van der Meer
- Rachelle N Palchesko
- Rebecca M. Duffy
- Rudolf Allert de Boer
- Yan Sun
Organizations
- Carnegie Mellon University
- Human Frontier Science Program
- National Institutes of Health
- Office of Naval Research
- University of Groningen