Neuronal delivery of antibodies has therapeutic effects in animal models of botulism
Abstract
Intraneuronal delivery of a therapeutic, single-domain antibody reverses botulism symptoms and increases survival of mice, guinea pigs, and monkeys.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 06, 2021
- Source ID
- 10.1126/scitranslmed.abd7789
Entities
People
- Celinia A Ondeck
- Cesar H Benjumea
- Charles B Shoemaker
- Christopher A Angeles
- Edwin Vazquez-Cintron
- Elliot J Glotfelty
- Jaclyn Cika
- James B Machamer
- Justin T Whitfield
- Konstantin Ichtchenko
- Kyle E. Kelly
- Luis Tenezaca
- Mark Mangkhalakhili
- Patrick M. McNutt
- Philip A. Band
Organizations
- City University of New York
- Defense Threat Reduction Agency
- National Institute of Allergy and Infectious Diseases
- New York University
- Tufts University
- United States Army Medical Research Institute of Chemical Defense
- Wake Forest School of Medicine