Identifying and targeting the Achilles heel of a recalcitrant cancer
Abstract
Targeting replication stress response proteins in small cell lung cancer activates the innate immune cGAS-STING pathway leading to augmentation of immunotherapy’s antitumor response.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 04, 2021
- Source ID
- 10.1126/scitranslmed.abj6946
Entities
People
- Triparna Sen
Organizations
- Lung Cancer Research Foundation
- Memorial Sloan Kettering Cancer Center
- National Institutes of Health
- Parker Institute for Cancer Immunotherapy
- United States Department of Defense