Search for a Shared Genetic or Biochemical Basis for Biofilm Tolerance to Antibiotics across Bacterial Species
Abstract
Is there a universal genetically programmed defense providing tolerance to antibiotics when bacteria grow as biofilms? A comparison between biofilms of three different bacterial species by transcriptomic and metabolomic approaches uncovered no evidence of one. Single-species biofilms of three bacterial species ( Pseudomonas aeruginosa , Staphylococcus aureus , and Acinetobacter baumannii ) were grown in vitro for 3 days and then challenged with respective antibiotics (ciprofloxacin, daptomycin, and tigecycline) for an additional 24 h.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 19, 2022
- Source ID
- 10.1128/aac.00021-22
Entities
People
- Anders Wallqvist
- Ben White
- Brendan M. Mumey
- Brian Bothner
- Francisco G. Vital-lopez
- Garth A. James
- Kerry S. Williamson
- Laura Boegli
- Liam Scott
- Michael J. Franklin
- Philip Stewart
- Timothy Hamerly
- Xiao Hu
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- Montana State University
- National Institute of General Medical Sciences
- United States Army
- United States Department of Defense