Preclinical Evaluation of Recombinant Microbial Glycoside Hydrolases as Antibiofilm Agents in Acute Pulmonary Pseudomonas aeruginosa Infection
Abstract
The bacterium Pseudomonas aeruginosa can colonize the airways of patients with chronic lung disease. Within the lung, P. aeruginosa forms biofilms that can enhance resistance to antibiotics and immune defenses. P. aeruginosa biofilm formation is dependent on the secretion of matrix exopolysaccharides, including Pel and Psl.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 16, 2022
- Source ID
- 10.1128/aac.00052-22
Entities
People
- Deepa Raju
- Donald C Sheppard
- Fabrice N. Gravelat
- Hanna Ostapska
- Ira Lacdao
- Melanie Lehoux
- Natalie C. Bamford
- P Lynne Howell
- Perrin Baker
- Piyanka Sivarajah
- Rachel Corsini
- Stephanie Gilbert
Organizations
- Canadian Glycomics Network
- Cystic Fibrosis Canada
- McGill University
- United States Army Materiel Command
- University of Toronto