Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei
Abstract
Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 15, 2023
- Source ID
- 10.1128/aac.00171-23
Entities
People
- Bart J. Currie
- Carina M. Hall
- David M Wagner
- Herbert P Schweizer
- Jason W. Sahl
- Jessica R Webb
- Johannah P. Hagen
- Mark Mayo
- Nawarat Somprasong
- Paul Keim
- Roxanne Nottingham
- Yuwana Podin
Organizations
- Charles Darwin University
- Defense Threat Reduction Agency
- Northern Arizona University
- Shionogi
- University of Melbourne