Effect of the Lysin Exebacase on Cardiac Vegetation Progression in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Endocarditis as Determined by Echocardiography
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) poses significant therapeutic challenges related to its frequency in clinical infections, innate virulence properties, and propensity for multiantibiotic resistance. MRSA is among the most common causes of endovascular infections, including infective endocarditis (IE). Our objective was to employ transthoracic echocardiography (TTE) to evaluate the effect of exebacase, a novel direct lytic agent, in experimental aortic valve MRSA IE.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 23, 2020
- Source ID
- 10.1128/aac.00482-20
Entities
People
- Arnold S. Bayer
- Cara Cassino
- Dario Lehoux
- James Iwaz
- Raymond Schuch
- Sonia U. Shah
- Wessam Abdelhady
- Yan Q. Xiong
- Youngju Pak
Organizations
- Harbor–UCLA Medical Center
- United States Department of Defense
- University of California, Los Angeles