Orally Bioavailable Endochin-Like Quinolone Carbonate Ester Prodrug Reduces Toxoplasma gondii Brain Cysts
Abstract
Toxoplasmosis is a potentially fatal infection for immunocompromised people and the developing fetus. Current medicines for toxoplasmosis have high rates of adverse effects that interfere with therapeutic and prophylactic regimens. Endochin-like quinolones (ELQs) are potent inhibitors of Toxoplasma gondii proliferation in vitro and in animal models of acute and latent infection. ELQ-316, in particular, was found to be effective orally against acute toxoplasmosis in mice and highly selective for T. gondii cytochrome b over human cytochrome b .
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 20, 2020
- Source ID
- 10.1128/aac.00535-20
Entities
People
- Aaron Nilsen
- Alyssa J. Miller
- Igor Bruzual
- J Stone Doggett
- Lev N. Zakharov
- Michael K. Riscoe
- Rolf Winter
- Rozalia A Dodean
- Sovitj Pou
- Tracey Schultz
- Vern B. Carruthers
Organizations
- National Institute of Allergy and Infectious Diseases
- Oregon Health & Science University
- Stanley Medical Research Institute
- United States Department of Defense
- United States Department of Veterans Affairs
- University of Michigan
- University of Oregon