Loss of RND-Type Multidrug Efflux Pumps Triggers Iron Starvation and Lipid A Modifications in Pseudomonas aeruginosa
Abstract
Transporters belonging to the r esistance- n odulation- d ivision (RND) superfamily of proteins are invariably present in the genomes of Gram-negative bacteria and are largely responsible for the intrinsic antibiotic resistance of these organisms. The numbers of genes encoding RND transporters per genome vary from 1 to 16 and correlate with the environmental versatilities of bacterial species. Pseudomonas aeruginosa strain PAO1, a ubiquitous nosocomial pathogen, possesses 12 RND pumps, which are implicated in the development of clinical multidrug resistance and known to contribute to virulence, quorum sensing, and many other physiological functions.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 17, 2021
- Source ID
- 10.1128/aac.00592-21
Entities
People
- Courtney E. Chandler
- Helen I Zgurskaya
- Herbert P Schweizer
- Inga V. Leus
- Justyna W. Adamiak
- Robert K Ernst
- Varsha Jhawar
- Vincent Bonifay
Organizations
- Defense Threat Reduction Agency
- National Institute of Allergy and Infectious Diseases
- Northern Arizona University
- University of Maryland, Baltimore
- University of Oklahoma