Effective Therapy Targeting Cytochrome bc 1 Prevents Babesia Erythrocytic Development and Protects from Lethal Infection
Abstract
An effective strategy to control blood-borne diseases and prevent outbreak recrudescence involves targeting conserved metabolic processes that are essential for pathogen viability. One such target for Plasmodium and Babesia , the infectious agents of malaria and babesiosis, respectively, is the mitochondrial cytochrome bc 1 protein complex, which can be inhibited by endochin-like quinolones (ELQ) and atovaquone.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 17, 2021
- Source ID
- 10.1128/aac.00662-21
Entities
People
- Aaron C. Nilsen
- Anasuya C. Pal
- Choukri Ben Mamoun
- Isaline Renard
- J Stone Doggett
- Jose Thekkiniath
- Joy E. Chiu
- Lisa Frueh
- Madelyn Kumar
- Michael K. Riscoe
- Pallavi Singh
- Pratap Vydyam
- Rolf W. Winter
- Rozalia A Dodean
- Shalev Gihaz
- Sovitj Pou
Organizations
- National Institutes of Health
- Steven & Alexandra Cohen Foundation
- United States Department of Defense
- United States Department of Veterans Affairs
- Yale School of Medicine