The Essential Role of Hypermutation in Rapid Adaptation to Antibiotic Stress
Abstract
A common outcome of antibiotic exposure in patients and in vitro is the evolution of a hypermutator phenotype that enables rapid adaptation by pathogens. While hypermutation is a robust mechanism for rapid adaptation, it requires trade-offs between the adaptive mutations and the more common “hitchhiker” mutations that accumulate from the increased mutation rate.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 01, 2019
- Source ID
- 10.1128/aac.00744-19
Entities
People
- Amy G. Prater
- Heer H. Mehta
- Henry S Gibbons
- Kathryn Beabout
- Mark Karavis
- Ryan A. L. Elworth
- Yousif Shamoo
Organizations
- Defense Threat Reduction Agency
- Edgewood Chemical Biological Center
- National Institutes of Health
- National Science Foundation
- Rice University