Mutations in rv0678 Confer Low-Level Resistance to Benzothiazinone DprE1 Inhibitors in Mycobacterium tuberculosis
Abstract
Tuberculosis (TB) is the leading cause of death from any bacterial infection, causing 1.5 million deaths worldwide each year. Due to the emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb) there have been significant efforts aimed at developing novel drugs to treat TB.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 20, 2022
- Source ID
- 10.1128/aac.00904-22
Entities
People
- Jeremy M. Rock
- Michael A. Dejesus
- Nicholas C. Poulton
- Zachary A. Azadian
Organizations
- National Institute of Allergy and Infectious Diseases
- The Rockefeller University
- United States Department of Defense