Screening Repurposing Libraries for Identification of Drugs with Novel Antifungal Activity
Abstract
Fungal organisms are ubiquitous in nature, and progress of modern medicine is creating an expanding number of severely compromised patients susceptible to a variety of opportunistic fungal infections. These infections are difficult to diagnose and treat, leading to high mortality rates. The limited antifungal arsenal, the toxicity of current antifungal drugs, the development of resistance, and the emergence of new multidrug-resistant fungi, all highlight the urgent need for new antifungal agents.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 20, 2020
- Source ID
- 10.1128/aac.00924-20
Entities
People
- Gina Wall
- Jose L Lopez-Ribot
Organizations
- National Institute of Allergy and Infectious Diseases
- United States Department of Defense
- University of Texas at San Antonio