Efflux Pumps of Burkholderia thailandensis Control the Permeability Barrier of the Outer Membrane
Abstract
Burkholderia comprises species that are significant biothreat agents and common contaminants of pharmaceutical production facilities. Their extreme antibiotic resistance affects all classes of antibiotics, including polycationic polymyxins and aminoglycosides. The major underlying mechanism is the presence of two permeability barriers, the outer membrane with modified lipid A moieties and active drug efflux pumps.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 01, 2019
- Source ID
- 10.1128/aac.00956-19
Entities
People
- Courtney E. Chandler
- Ganesh Krishnamoorthy
- Haotian Xue
- Helen I Zgurskaya
- Herbert P Schweizer
- Jon W. Weeks
- Robert K Ernst
- Zhen Zhang
Organizations
- Defense Threat Reduction Agency
- National Institute of Allergy and Infectious Diseases
- University of Florida
- University of Oklahoma