Demonstration of the Broad-Spectrum In Vitro Activity of Finafloxacin against Pathogens of Biodefense Interest
Abstract
This study investigated the in vitro activity of finafloxacin against bacterial strain panels of the biodefense pathogens. Broth microdilution assays were performed at neutral and acidic pH to determine the effectiveness of the antibiotics under conditions typical of an intracellular environment. In all instances, finafloxacin demonstrated superior activity at low pH.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 01, 2019
- Source ID
- 10.1128/aac.01470-19
Entities
People
- Christine Bentley
- Kay B. Barnes
- Lynda L. Miller
- Mark I. Richards
- Paul S. Russell
- Purvi D. Desai
- Sarah V. Harding
- Stephanie A. Halasohoris
- Steven D. Zumbrun
Organizations
- Defence Science and Technology Laboratory
- United States Army Medical Research Institute of Infectious Diseases
- United States Department of Defense