Prevalence of Quinolone Resistance in Enterobacteriaceae from Sierra Leone and the Detection of qnrB Pseudogenes and Modified LexA Binding Sites
Abstract
A collection of 74 Enterobacteriaceae isolates found in Bo, Sierra Leone, were tested for quinolone antibiotic susceptibility and resistance mechanisms. The majority of isolates (62%) were resistant to quinolones, and 61% harbored chromosomal gyrA and/or parC mutations. Plasmid-mediated quinolone resistance genes were ubiquitous, with qnrB and aac(6′)-Ib-cr being the most prevalent. Mutated LexA binding sites were found in all qnrB1 genes, and truncated qnrB pseudogenes were found in the majority of Citrobacter isolates.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 01, 2016
- Source ID
- 10.1128/aac.01576-16
Entities
People
- Chris R. Taitt
- Daniel Chae
- David A. Stenger
- Gary J Vora
- Michael G. Stockelman
- Rashid Ansumana
- Tomasz Leski
- Umaru Bangura
Organizations
- Defense Threat Reduction Agency
- Njala University
- Office of Naval Research
- Thomas Jefferson High School for Science and Technology
- United States Naval Research Laboratory