Analysis of the Potential for N 4 -Hydroxycytidine To Inhibit Mitochondrial Replication and Function
Abstract
N 4 -Hydroxycytidine (NHC) is an antiviral ribonucleoside analog that acts as a competitive alternative substrate for virally encoded RNA-dependent RNA polymerases. It exhibits measurable levels of cytotoxicity, with 50% cytotoxic concentration values ranging from 7.5 μM in CEM cells and up to >100 μM in other cell lines.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 27, 2020
- Source ID
- 10.1128/aac.01719-19
Entities
People
- Alexander A. Kolykhalov
- David B. Guthrie
- Deborah G. Mitchell
- Gaofei Lu
- George R. Painter
- Gregory R Bluemling
- Joshua Marlow
- Levi Moellering
- Michael G. Natchus
- Zachary M Sticher
Organizations
- Defense Threat Reduction Agency
- Emory University