Measurements of 5,6-Orthoquinone, a Surrogate for the Presumed Active Primaquine Metabolite 5-Hydroxyprimaquine, in the Urine of Cambodian Adults
Abstract
The active metabolites of primaquine, in particular 5-hydroxyprimaquine, likely responsible for the clearance of dormant hypnozoites, are produced through the hepatic CYP450 2D6 (CYP2D6) enzymatic pathway. With the inherent instability of 5-hydroxyprimaquine, a stable surrogate, 5,6-orthoquinone, can now be detected and measured in the urine as part of primaquine pharmacokinetic studies.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 15, 2022
- Source ID
- 10.1128/aac.01821-21
Entities
People
- Brandon Pybus
- Brian Vesely
- Chanikarn Kodchakorn
- Charlotte Lanteri
- Darapiseth Sea
- David Saunders
- Gregory Reichard
- Huy Rekol
- Jason Bennett
- Kong Nareth
- Lek Dysoley
- Mali Ittiverakul
- Mariusz Wojnarski
- Mark Fukuda
- Michele D Spring
- Montri Arsanok
- Nillawan Buathong
- Norman C. Waters
- Pattaraporn Vanachayangkul
- Pheaktra Oung
- Philip L. Smith
- Samon Nou
- Sohei Hom
- Sok Chandara
- Sokna Ly
- Somethy Sok
- Thay Kheang Heng
- Winita Ta-aksorn
- Worachet Kuntawunginn
Organizations
- Defense Health Agency
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- Uniformed Services University of the Health Sciences
- United States Army
- United States Department of Defense
- Walter Reed Army Institute of Research