In Vitro Antibacterial Activity and In Vivo Efficacy of Sulbactam-Durlobactam against Pathogenic Burkholderia Species
Abstract
The Gram-negative bacterial genus Burkholderia includes several hard-to-treat human pathogens: two biothreat species, Burkholderia mallei (causing glanders) and B. pseudomallei (causing melioidosis), and the B. cepacia complex (BCC) and B. gladioli , which cause chronic lung infections in persons with cystic fibrosis. All Burkholderia spp. possess an Ambler class A Pen β-lactamase, which confers resistance to β-lactams.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 17, 2021
- Source ID
- 10.1128/aac.01930-20
Entities
People
- Adam B Shapiro
- Alita A Miller
- Douglas J. Lane
- Elise T. Zeiser
- John J. Lipuma
- John P. Mueller
- John P. O'donnell
- Krisztina M Papp-Wallace
- Rekha G. Panchal
- Scott A. Becka
Organizations
- Biomedical Laboratory Research and Development, VA Office of Research and Development
- Case Western Reserve University
- Cystic Fibrosis Foundation
- Defense Threat Reduction Agency
- Entasis Therapeutics