Finafloxacin Is an Effective Treatment for Inhalational Tularemia and Plague in Mouse Models of Infection
Abstract
Infection with aerosolized Francisella tularensis or Yersinia pestis can lead to lethal disease in humans if treatment is not initiated promptly. Finafloxacin is a novel fluoroquinolone which has demonstrated broad-spectrum activity against a range of bacterial species in vitro, in vivo , and in humans, activity which is superior in acidic, infection-relevant conditions.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 18, 2021
- Source ID
- 10.1128/aac.02294-20
Entities
People
- Alejandro Nunez
- Christine Bentley
- Joanne E. Thwaite
- Kay B. Barnes
- Mark I. Richards
- Sarah V. Harding
- Thomas R Laws
Organizations
- Animal and Plant Health Agency
- Defence Science and Technology Laboratory
- United States Department of Defense