The Cationic Antimicrobial Peptide Activity of Lysozyme Reduces Viable Enterococcus faecalis Cells in Biofilms
Abstract
Enterococcus faecalis , a leading cause of health care-associated infections, forms biofilms and is resistant to many antimicrobial agents. Planktonic-phase E. faecalis is resistant to high concentrations of the enzyme lysozyme, which catalyzes the hydrolysis of N -acetylmuramic acid and N -acetylglucosamine linkages in peptidoglycan and is also a cationic antimicrobial peptide (CAMP). E. faecalis lysozyme resistance in planktonic cells is stimulated upon activation of the extracytoplasmic function sigma factor SigV via cleavage of the anti-sigma factor RsiV by the transmembrane protease Eep.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 17, 2022
- Source ID
- 10.1128/aac.02339-21
Entities
People
- Arielle J. Weinstein
- Candace N. Rouchon
- Joann Harris
- Kristi L Frank
- Mohammad Roky
- Zahra Zubair-nizami
Organizations
- American Heart Association
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- National Institutes of Health
- Uniformed Services University of the Health Sciences
- United States Department of Defense