Metabolic Survival Adaptations of Plasmodium falciparum Exposed to Sublethal Doses of Fosmidomycin
Abstract
The malaria parasite Plasmodium falciparum contains the apicoplast organelle that synthesizes isoprenoids, which are metabolites necessary for posttranslational modification of Plasmodium proteins. We used fosmidomycin, an antibiotic that inhibits isoprenoid biosynthesis, to identify mechanisms that underlie the development of the parasite’s adaptation to the drug at sublethal concentrations.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 18, 2021
- Source ID
- 10.1128/aac.02392-20
Entities
People
- Anders Wallqvist
- Jaques Reifman
- Krithika Rajaram
- Russell P Swift
- Sean T Prigge
- Shivendra G Tewari
Organizations
- Bloomberg Family Foundation
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health
- Johns Hopkins University
- National Institutes of Health
- United States Department of Defense