A Nonlethal Murine Flame Burn Model Leads to a Transient Reduction in Host Defenses and Enhanced Susceptibility to Lethal Pseudomonas aeruginosa Infection
Abstract
Of the 486,000 burn injuries that required medical treatment in the United States in 2016, 40,000 people were hospitalized, with >3,000 fatalities. After burn injury, humans are at increased risk of sepsis and mortality from infections caused by Pseudomonas aeruginosa , an opportunistic pathogen.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 16, 2021
- Source ID
- 10.1128/iai.00091-21
Entities
People
- Adrienne R. Kambouris
- Alan S. Cross
- Catriona Miller
- Gary Fiskum
- Jerod Brammer
- Kerri Lopez
- Myeongjin Choi
- Raphael Simon
- Scott M. Baliban
- Stefanie N. Vogel
- Wei Chao
- Yousef Al-abed
Organizations
- Centre Pour le Développement des Vaccins-Mali
- National Institutes of Health
- The Feinstein Institute for Medical Research
- United States Air Force
- United States Air Force School of Aerospace Medicine
- University of Maryland School of Medicine