A Potent and Effective SuicidalListeriaVaccine Platform
Abstract
Live-attenuatedListeria monocytogeneshas shown encouraging potential as an immunotherapy platform in preclinical and clinical settings. However, additional safety measures will enable application across malignant and infectious diseases. Here, we describe a new vaccine platform, termed Lm-RIID (L. monocytogenesrecombinase-induced intracellular death), that induces the deletion of genes required for bacterial viability yet maintains potent T cell responses to encoded antigens.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 01, 2019
- Source ID
- 10.1128/iai.00144-19
Entities
People
- Chen Chen
- Chris S. Rae
- Daniel A. Portnoy
- Dirk G. Brockstedt
- Edward E. Lemmens
- Erin L. Benanti
- Justin Skoble
- Marcella Fassò
- Meredith L. Leong
- Peter Lauer
- Thomas W. Dubensky Jr.
- Weiqun Liu
- William G. Hanson
Organizations
- National Institutes of Health