Coxiella burnetii Intratracheal Aerosol Infection Model in Mice, Guinea Pigs, and Nonhuman Primates
Abstract
Coxiella burnetii, the etiological agent of Q fever, is a Gram-negative bacterium transmitted to humans by inhalation of contaminated aerosols. Acute Q fever is often self-limiting, presenting as a febrile illness that can result in atypical pneumonia. In some cases, Q fever becomes chronic, leading to endocarditis that can be life threatening. The formalin-inactivated whole-cell vaccine (WCV) confers long-term protection but has significant side effects when administered to presensitized individuals.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 01, 2019
- Source ID
- 10.1128/iai.00178-19
Entities
People
- A. E. Gregory
- A. P. Fratzke
- E. J. Van Schaik
- J. E. Samuel
- K. E. Russell-lodrigue
Organizations
- Defense Threat Reduction Agency
- National Institute of Allergy and Infectious Diseases
- Tulane University of Louisiana