Multicomponent Pseudomonas aeruginosa Vaccines Eliciting Th17 Cells and Functional Antibody Responses Confer Enhanced Protection against Experimental Acute Pneumonia in Mice

Abstract

The Gram-negative pathogen Pseudomonas aeruginosa is a common cause of pneumonia in hospitalized patients. Its increasing antibiotic resistance and widespread occurrence present a pressing need for vaccines.

Document Details

Document Type
Pub Defense Publication
Publication Date
Oct 20, 2022
Source ID
10.1128/iai.00203-22

Entities

People

  • Antonio DiGiandomenico
  • Christina Merakou
  • David E. Tabor
  • David Zurakowski
  • Gregory Priebe
  • Marco DiBlasi
  • Margaret Kehl
  • Matthew M Schaefers
  • Mohammad Omar Faruk Shaikh
  • Sarah Bonney
  • Tiffany Liao

Organizations

  • AstraZeneca
  • Boston Children's Hospital
  • Harvard Medical School
  • United States Department of Defense

Tags

Readers

  • Infectious Disease/Epidemiology
  • Microbial Pathology
  • Powder metallurgy of Titanium alloys.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech