Coxiella burnetii Epitope-Specific T-Cell Responses in Patients with Chronic Q Fever
Abstract
Infection with Coxiella burnetii , the causative agent of Q fever, can result in life-threatening persistent infection. Reactogenicity hinders worldwide implementation of the only licensed human Q fever vaccine. We previously demonstrated long-lived immunoreactivity in individuals with past symptomatic and asymptomatic Coxiella infection (convalescents) to promiscuous HLA class II C. burnetii epitopes, providing the basis for a novel T-cell targeted subunit vaccine.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 01, 2019
- Source ID
- 10.1128/iai.00213-19
Entities
People
- Anja Garritsen
- Anja Scholzen
- Ann E Sluder
- Anne S. De Groot
- Chantal P. Bleeker-rovers
- Eva Hartman
- Guilhem Richard
- Leonard Moise
- Mark C. Poznansky
- Patrick M. Reeves
- Susan Raju Paul
- William D. Martin
Organizations
- Defense Threat Reduction Agency
- Massachusetts General Hospital
- Radboud University Medical Centre
- University of Rhode Island