Evaluation of the Immunogenicity and Protective Efficacy of an Enterotoxigenic Escherichia coli CFA/I Adhesin–Heat-Labile Toxin Chimera
Abstract
Recent efforts to develop an enterotoxigenic Escherichia coli (ETEC) vaccine have focused on the antigenically conserved tip adhesins of colonization factors. We showed previously that intranasal immunization with dsc 19 CfaE, a soluble variant of the in cis donor strand-complemented tip adhesin of a colonization factor of the class 5 family (CFA/I) fimbria, is highly immunogenic and protects against oral challenge with CFA/I-positive (CFA/I + ) ETEC strain H10407 in the Aotus nancymaae nonhuman primate.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 19, 2020
- Source ID
- 10.1128/iai.00252-20
Entities
People
- Aisling O’dowd
- Annette L. Mcveigh
- Colleen M. Woods
- Julianne E. Rollenhagen
- Michael G. Jobling
- Michael G. Prouty
- Michael J Gregory
- Milton Maciel
- Randall K. Holmes
- Ryan C. Maves
- Stephanie A. Sincock
- Stephen J. Savarino
- Steven T Poole
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- National Institutes of Health
- Naval Medical Research Center
- Uniformed Services University of the Health Sciences
- United States Army
- University of Colorado School of Medicine