MRSA Isolates from Patients with Persistent Bacteremia Generate Nonstable Small Colony Variants In Vitro within Macrophages and Endothelial Cells during Prolonged Vancomycin Exposure
Abstract
Staphylococcus aureus (especially methicillin-resistant S. aureus [MRSA]) is frequently associated with persistent bacteremia (PB) during vancomycin therapy despite consistent susceptibility in vitro . Strategic comparisons of PB strains versus those from vancomycin-resolving bacteremia (RB) would yield important mechanistic insights into PB outcomes.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 24, 2023
- Source ID
- 10.1128/iai.00423-22
Entities
People
- Arnold S. Bayer
- David E. Heinrichs
- Liana C. Chan
- Mariya I Goncheva
- Michael R. Yeaman
- Ronald S Flannagan
- Thiago Fauerharmel-nunes
- Vance G. Fowler Jr.
- Yan Q. Xiong
Organizations
- Canadian Institutes of Health Research
- Duke University
- Harbor–UCLA Medical Center
- National Institute of Allergy and Infectious Diseases
- United States Department of Defense
- University of California, Los Angeles
- Western University