The Impacts of msaABCR on sarA -Associated Phenotypes Are Different in Divergent Clinical Isolates of Staphylococcus aureus
Abstract
The staphylococcal accessory regulator ( sarA ) plays an important role in Staphylococcus aureus infections, including osteomyelitis, and the msaABCR operon has been implicated as an important factor in modulating expression of sarA . Thus, we investigated the contribution of msaABCR to sarA -associated phenotypes in the S. aureus clinical isolates LAC and UAMS-1. Mutation of msaABCR resulted in reduced production of SarA and a reduced capacity to form a biofilm in both strains.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 22, 2020
- Source ID
- 10.1128/iai.00530-19
Entities
People
- Aura M. Ramirez
- Gyan S. Sahukhal
- Joseph S. Rom
- Karen E. Beenken
- Mark S Smeltzer
- Mohamed O. Elasri
Organizations
- Congressionally Directed Medical Research Programs
- National Center for Research Resources
- National Institute of Allergy and Infectious Diseases
- National Institute of General Medical Sciences
- University of Arkansas for Medical Sciences
- University of Southern Mississippi