Staphylococcus aureus and Acinetobacter baumannii Inhibit Osseointegration of Orthopedic Implants
Abstract
Bacterial infections routinely cause inflammation and thereby impair osseointegration of orthopedic implants.Acinetobacterspp., which cause osteomyelitis following trauma, on or off the battlefield, were, however, reported to cause neither osteomyelitis nor osteolysis in rodents. We therefore compared the effects ofAcinetobacterstrain M2 to those ofStaphylococcus aureusin a murine implant infection model. Sterile implants and implants with adherent bacteria were inserted in the femur of mice.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 17, 2022
- Source ID
- 10.1128/iai.00669-21
Entities
People
- Bryan S. Hausman
- Edward M. Greenfield
- Hyonmin Choe
- Joscelyn M. Tatro
- Kristine M. Hujer
- Ozan Akkus
- Phillip N. Rather
- Robert A Bonomo
- Steve H. Marshall
- Zhenghong Lee
Organizations
- Case Western Reserve University
- Emory University
- Indiana University
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- National Institute of Allergy and Infectious Diseases
- United States Department of Defense
- United States Department of Veterans Affairs
- Yokohama City University