Fighting Persistence: How Chronic Infections with Mycobacterium tuberculosis Evade T Cell-Mediated Clearance and New Strategies To Defeat Them
Abstract
Chronic bacterial infections are caused by pathogens that persist within their hosts and avoid clearance by the immune system. Treatment and/or detection of such pathogens is difficult, and the resulting pathologies are often deleterious or fatal. There is an urgent need to develop protective vaccines and host-directed therapies that synergize with antibiotics to prevent pathogen persistence and infection-associated pathologies. However, many persistent pathogens, such as Mycobacterium tuberculosis , actively target the very host pathways activated by vaccination.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 22, 2020
- Source ID
- 10.1128/iai.00916-19
Entities
People
- Andrew Olive
- Laurisa Ankley
- Sean Thomas
Organizations
- Michigan State University
- National Institutes of Health
- United States Department of Defense