The Factor H-Binding Site of CspZ as a Protective Target against Multistrain, Tick-Transmitted Lyme Disease
Abstract
The spirocheteBorrelia burgdorferisensu latois the causative agent of Lyme disease (LD). The spirochetes produce the CspZ protein that binds to a complement regulator, factor H (FH). Such binding downregulates activation of host complement to facilitate spirochete evasion of complement killing. However, vaccination with CspZ does not protect against LD infection. In this study, we demonstrated that immunization with CspZ-YA, a CspZ mutant protein with no FH-binding activity, protected mice from infection by several spirochete genotypes introduced via tick feeding.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 20, 2020
- Source ID
- 10.1128/iai.00956-19
Entities
People
- Ashley L. Marcinkiewicz
- Ilva Lieknina
- Jennifer Yates
- Kaspars Tars
- Maria Elena Bottazzi
- Nicholas J. Mantis
- Patricia L. Lederman
- Peter Kraiczy
- Thomas M. Hart
- Utpal Pal
- Wen-hsiang Chen
- Xiuli Yang
- Yi-Pin Lin
Organizations
- Baylor University
- Latvian Biomedical Research and Study centre
- National Institute of Allergy and Infectious Diseases
- National Science Foundation
- New York State Department of Health
- State University of New York at Albany
- Texas Children's Hospital
- United States Department of Defense
- University of Maryland
- Wadsworth Center