Disruption of the tagF Orthologue in the epa Locus Variable Region of Enterococcus faecalis Causes Cell Surface Changes and Suppresses an eep -Dependent Lysozyme Resistance Phenotype
Abstract
Enterococcus faecalis is a leading cause of health-care-associated infections for which there are limited treatment options. E. faecalis is resistant to several antibiotics and to high concentrations of the human antimicrobial enzyme lysozyme. The molecular mechanisms that mediate lysozyme resistance in E. faecalis are complex and remain incompletely characterized.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 18, 2022
- Source ID
- 10.1128/jb.00247-22
Entities
People
- Arielle J. Weinstein
- Candace N. Rouchon
- Carissa A. Hutchison
- Kristi L Frank
- Petra L. Kohler
- Zahra B. Zubair-nizami
Organizations
- Henry M. Jackson Foundation
- National Institute of Allergy and Infectious Diseases
- Uniformed Services University of the Health Sciences
- University of Minnesota