Identification of a Fifth Antibacterial Toxin Produced by a Single Bacteroides fragilis Strain
Abstract
The intestinal microbiota is a diverse microbial ecosystem that provides numerous benefits to humans. The factors that govern its establishment and stability are just beginning to be elucidated. Identification and characterization of antimicrobial toxins produced by its members and their killing range are essential to understanding the role of antagonism in community composition and stability. Here, we identify a fifth antimicrobial toxin produced by a single Bacteroides fragilis strain and identify its target. The finding of such a large number of toxins that antagonize competing members suggests that this feature substantially contributes to the fitness of these bacteria. In addition, these toxins may have applications in genetically engineered gut bacteria to allow engraftment or to antagonize a potentially pathogenic member.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 15, 2019
- Source ID
- 10.1128/jb.00577-18
Entities
People
- Andrew M. Shumaker
- Laurie E. Comstock
- Michael J. Coyne
- Pamela Silver
- Valentina Laclare Mceneany
Organizations
- Harvard Medical School
- National Institutes of Health